Effect of Phenoxybenzamine on Phagocytic Activity and Shock Mortality in the Rat.

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Abstract
Summary Phenoxybenzamine (PBZ—0.5 mg/kg) decreased, and blockade of the reticulosndothelial system with colloidal carbon (320 mg/kg) temporarily increased the mortality of rats to subsequent tumbling shock. The usual protective effect of PBZ was lost if the drug was given after carbon blockade; in contrast, PBZ maintained its protective effect if given before blockade although “acute” traumatic deaths incident to drumming increased. PBZ pretreatment had no effect on pre-shock or post-shock carbon clearance activity either in the intact rat or in the in situ perfused liver. The results indicate that in the rat carbon clearance activity is not well correlated with the protective action of PBZ in traumatic shock. We express our thanks to Smith, Kline and French Laboratories, Philadelphia, Pa., for phenoxybenzaminc hydrochloride (Lot 127-DI-(1)) used in this study.

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