Lactulose as an antiendotoxin in experimental colitis
- 1 April 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 82 (4) , 469-472
- https://doi.org/10.1002/bjs.1800820413
Abstract
The efficacy of lactulose as an antiendotoxin was studied and the effect of lactulose or colistin on faecal flora was investigated in a hapten-induced rat model of colitis. Enteral administration of lactulose to rats with colitis was associated with a significant reduction in the systemic concentration of endotoxin (median (range) 5.4 (0–19.9) versus 23.7 (0–145.0) pg/ml in colitic rats treated with water; 4.6 (0–10.8) pg/ml in healthy animals). Enteral administration of colistin significantly reduced the faecal count of aerobic Gram-negative bacilli (median (range) 2.84 (1.40–8.43) versus 8.26 (4.50–10.40) log10 colony-forming units per g faeces after treatment with water) but not the faecal load of endotoxin. Patients with inflammatory bowel disease may benefit from enteral treatment with lactulose to prevent systemic endotoxaemia and/or with colistin to modify enteric bacteria.Keywords
Funding Information
- Eastern Health and Social Services Board, Northern Ireland
This publication has 24 references indexed in Scilit:
- Adsorbents as antiendotoxin agents in experimental colitis.Gut, 1993
- Role of Intestinal Microflora in Initiation and Perpetuation of Inflammatory Bowel DiseaseCanadian Journal of Gastroenterology and Hepatology, 1990
- Experimental and clinical study of lactulose in obstructive jaundiceBritish Journal of Surgery, 1986
- Endotoxaemia in active Crohn's disease. Treatment with whole gut irrigation and 5-aminosalicylic acid.Gut, 1986
- Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgeryBritish Journal of Surgery, 1984
- Increased incidence of faecal coliforms with in vitro adhesive and invasive properties in patients with ulcerative colitis.Gut, 1980
- Agglutinins to bacteria in Crohn's disease.Gut, 1980
- Influence of inflammatory bowel disease on intestinal microflora.Gut, 1978
- Lipoid-A-Antikörpertiter bei Morbus CrohnKlinische Wochenschrift, 1976
- PORTAL BACTERÆMIA IN CASES OF ULCERATIVE COLITIS SUBMITTED TO COLECTOMYThe Lancet, 1969