Valproic acid and plasma levels of phenytoin
- 1 June 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 29 (6) , 904
- https://doi.org/10.1212/wnl.29.6.904
Abstract
Eight patients were treated concurrently with a constant dose of phenytoin and valproic acid for 1 year. During initial therapy with valproic acid, total plasma phenytoin levels decreased. The interaction was transient and was not observed at the end of 1 year. Total plasma phenytoin levels returned to pre-valproic-acid levels in seven patients.This publication has 4 references indexed in Scilit:
- Valproic acid Interaction with other anticonvulsant drugsNeurology, 1978
- Sodium valproate in the treatment of intractable seizure disordersNeurology, 1978
- Effect of sodium valproate on plasma protein binding of diphenylhydantoin.Journal of Neurology, Neurosurgery & Psychiatry, 1977
- SODIUM VALPROATE IN the TREATMENT of RESISTANT EPILEPSYActa Neurologica Scandinavica, 1976