Decreased CSF hypocretin-1 (orexin-A) after acute haemorrhagic brain injury

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Abstract
Nine patients from a previously reported cohort3 and 21 controls (seven women and five men, median age 38 years, range 17 to 70) with other neurological disease were enrolled in the study (table 1). The patient group included five subjects with intracerebral haemorrhage and five with subarachnoid haemorrhage (table 1). All patients had extraventricular drains inserted within a median of two days of disease onset (range 2 to 36) as a treatment procedure because of increasing signs of hydrocephalus. Morning CSF samples were collected twice: first between day 1 and day 2 after catheter insertion, and second between day 4 and day 10. Patients were assessed using the Glasgow coma scale (GCS) at presentation and the Glasgow outcome score (GOS) after three months.

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