COMBINED EXPOSURE TO DEET (N,N-DIETHYL-m-TOLUAMIDE) AND PERMETHRIN-INDUCED RELEASE OF RAT BRAIN MITOCHONDRIAL CYTOCHROMEc
- 22 June 2001
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health, Part A
- Vol. 63 (4) , 243-252
- https://doi.org/10.1080/15287390151143640
Abstract
The release of cytochrome c from the mitochondrial intermembrane space can induce apoptosis. The levels of mitochondrial cytochrome c in rat brain following a single dermal dose of 400 mg/kg of DEET, and of 1.3 mg/kg of permethrin, alone or in combination were determined. Rats were sacrificed at a time interval of 0.5, 1, 2, 4, 8, 16, 24, 48, or 72 h after dosing. Brain mitochondria were isolated and the levels of cytochrome c were measured using reversed-phase high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection. Average percentage recovery of cytochrome cKeywords
This publication has 0 references indexed in Scilit: