Bioavailability of conventional and slow-release oxprenolol in fasted and nonfasted individuals.
Open Access
- 1 March 1979
- journal article
- clinical trial
- Published by Wiley
- Vol. 7 (3) , 299-302
- https://doi.org/10.1111/j.1365-2125.1979.tb00936.x
Abstract
1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow-release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half-lives were longer after food with conventional tablets, presumably due to continued absorption. The opposite effect was seen with slow-release tablets. 3 Slow-release oxprenolol is, under the conditions of this study, a reliable and convenient dosage form, providing similar plasma-drug profiles in fasted and nonfasted individuals.Keywords
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