Regioisomeric 5(3)‐Aminomethyl‐3(5)‐phenylisoxazoles: Synthesis, Spectroscopic Discrimination, and Muscarinic Activity
- 1 January 1995
- journal article
- Published by Wiley in Archiv der Pharmazie
- Vol. 328 (5) , 437-443
- https://doi.org/10.1002/ardp.19953280508
Abstract
The regioselective synthesis of isomeric 5(3)-aminomethyl-3(5)-phenyl isoxazoles using different methods is described. Spectroscopic data, especially mass spectrometric fragmentation, were used to identify and characterize the regioisomers. The muscarinic activity of these isoxazoles was assayed on isolated guinea-pig ileum and atria as well as on isolated rabbit vas deferens.Keywords
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