K-582, a new peptide antibiotic. I.
- 31 December 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (6) , 533-542
- https://doi.org/10.7164/antibiotics.33.533
Abstract
A new basic peptide antibiotic designated as K582 was isolated, purified and characterized. When K582 was applied to a column of Al2O3 or Bio-Gel P-2 or CM Sephadex, 2 major peaks which were named Fraction I (K 582A) and Fraction II (K 582B) were obtained. The N content, the behavior in color reaction, the absorption bands of amide linkages in the IR absorption spectrum, 1H NMR spectrum and 13C NMR spectrum indicated the peptide nature of K 582A and K 582 B. K 582 was effective against yeasts, but inactive against other gram-positive bacteria, gram-negative bacteria and Mycobacterium. The toxicity was low in mice.This publication has 1 reference indexed in Scilit:
- The genus MetarhiziumTransactions of the British Mycological Society, 1976