The Polarity Protein Par-3 Directly Interacts with p75 NTR to Regulate Myelination
- 3 November 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 314 (5800) , 832-836
- https://doi.org/10.1126/science.1134069
Abstract
Cell polarity is critical in various cellular processes ranging from cell migration to asymmetric cell division and axon and dendrite specification. Similarly, myelination by Schwann cells is polarized, but the mechanisms involved remain unclear. Here, we show that the polarity protein Par-3 localizes asymmetrically in Schwann cells at the axon-glial junction and that disruption of Par-3 localization, by overexpression and knockdown, inhibits myelination. Additionally, we show that Par-3 directly associates and recruits the p75 neurotrophin receptor to the axon-glial junction, forming a complex necessary for myelination. Together, these results point to a critical role in the establishment of cell polarity for myelination.Keywords
This publication has 21 references indexed in Scilit:
- The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesisNature Cell Biology, 2006
- Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPasesProceedings of the National Academy of Sciences, 2004
- Axonal Neuregulin-1 Regulates Myelin Sheath ThicknessScience, 2004
- Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathwayProceedings of the National Academy of Sciences, 2003
- Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase ActivityCell, 2003
- The Neurotrophin Receptor p75 NTR as a Positive Modulator of MyelinationScience, 2002
- Neurotrophin signaling through the p75 neurotrophin receptorProgress in Neurobiology, 2002
- Neurotrophins are key mediators of the myelination program in the peripheral nervous systemProceedings of the National Academy of Sciences, 2001
- An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3The Journal of cell biology, 1998
- Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryosCell, 1995