Hepatocarcinogenicity of Diethylnitrosamine to the Self-Fertilizing Hermaphroditic Fish Rivulus marmoratus (Teleostomi: Cyprinodontidae)2
- 1 October 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 73 (4) , 871-876
- https://doi.org/10.1093/jnci/73.4.871
Abstract
The larvae, 3 days post hatching, of self-fertilizing hermaphroditic fish Rivulus marmoratus were exposed to diethyl-nitrosamine (DENA) (CAS: 55-18-5; N-nitrosodiethylamine) at levels of 50–400 ppm for 2 hours. At 3-month intervals, the exposed fish were sampled until 9 months postcarcinogen treatment. Hepatomas were induced in 6- and 9- month groups of the 100- ppm-treated and 200-ppm-treated fish. An exposure of fish larvae to 400 ppm DENA also produced similar tumors on 3-, 6-, and 9- month groups. The tumor incidences were clearly dose dependent. These results offered the possibility of the use of R. marmoratus as a suitable model for experimental carcinogenesis.Keywords
This publication has 1 reference indexed in Scilit:
- Temperature-induced meristic variation among three homozygous genotypes (clones) of the self-fertilizing fish Rivulus marmoratusCanadian Journal of Zoology, 1976