The effects of tumour extract on macrophage proliferation in lymph-nodes

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Abstract
Injection of a soluble [rat Rd/3] tumor extract induces mitosis in [rat] sinus macrophages of the draining lymph-node. This is not abolished by irradiation; the stimulus also induces monocytosis somewhat later [probably occurring as a result of an inflammatory reaction]. These findings make it likely that the stimulus induces mitosis in the resident lymph-node macrophage population.