Productive Replication of Human Adenoviruses in Mouse Epidermal Cells
Open Access
- 15 March 2000
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 74 (6) , 2895-2899
- https://doi.org/10.1128/jvi.74.6.2895-2899.2000
Abstract
In contrast to most cells of mouse origin, cell lines derived from mouse epidermis are permissive for replication of human adenovirus type 5. The extent of epidermal cell differentiation correlated with the level of E1A expression and virus replication. Mouse epidermal cells may provide useful models for cancer therapy using replication-competent human adenoviruses.Keywords
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