The Use of Polymer-Bound Triphenylphosphine and Carbon Tetrachloride for Condensation ofN-Alkoxycarbonyl α-Amino Acids and Primary Amines
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (11) , 1093-1095
- https://doi.org/10.1055/s-1992-26312
Abstract
The combination of carbon tetrachloride and polymer-bound tri-phenylphosphine is shown to be useful for coupling N-alkoxycarbonyl α-amino acids and primary amines including amino acid esters. The three major N-protecting groups, CBz, Boc, and FMOC are well tolerated. The product amides are isolated in 78-100% yields with negligible epimerization of the α-carbon.Keywords
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