Pathogenesis of Experimental Allergic Orchitis

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Abstract
Experimental allergic orchitis (EAO) was passively transferred among histocompatible guinea pigs (strain 13) by lymph node cells from animals immunized with sperm in complete Freund's adjuvant. Systemic injection of sensitized lymph node cells inconsistently produced at best mild lesions in recipients. However, local transfer of cells into the interstitium of the testes initiated severe changes of EAO within 4 to 8 days. The lesion, identical to that observed in the primary disease, was characterized by an intratubular infiltration by monocytes that preceded degeneration of the germinal epithelium. The monocytes were of host origin and their precursors were radiosensitive. The lymph node cells had to be live and from a guinea pig immune to sperm for transfer of EAO.

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