Inhibition of active intestinal sugar transport by digitalis

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Abstract
Ouabain or thevetin ( 10-5 [image]) inhibits the mucosal-to-serosal flux of 3-O-methylglucose only if present in the serosal but not if in the mucosal compartment. Digitoxin (10[long dash]4[image]) inhibits if put in either compartment because it passes rapidly across the gut wall. The site of inhibition of the intestinal sugar pump thus is identical with that of the Na pump. These findings support the theory that a functioning Na pump is essential for the activation of the sugar pump in the small intestine, but they do not suggest a direct Na effect on the sugar carrier.

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