THE PRODUCTION OF SEBUM IN YOUNG RATS: EFFECTS OF AGE, SEX, HYPOPHYSECTOMY AND TREATMENT WITH SOMATOTROPHIC HORMONE AND SEX HORMONES

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Abstract
SUMMARY: The secretion rate of sebum in rats aged 3–14 weeks was determined by measuring the amount of acetone-extractable skin surface lipids produced during 2 days. The results were expressed as mg. sebum/100 g. body weight/2 days. The secretion rate of male rats was found to increase with age (from 16 mg./100 g. at 3 weeks to 35 mg./100 g. at 14 weeks), while that of female rats (16 mg./100 g.) remained unchanged. Hypophysectomy of 3-week-old female rats resulted in lowering of the secretion rate to 13 mg./100 g. at 10 weeks. No change in the secretion rate of the hypophysectomized animals occurred during either growth hormone or oestradiol treatment, but testosterone in doses of 1 mg. and 0·2 mg./day increased sebum production (to 37 mg./100 g. and 24 mg./100 g., respectively). The increase obtained with testosterone (0·2 mg./day) was smaller (20 mg./100 g.), when oestradiol (3 μg./day) was given simultaneously.

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