Modeling the leech heartbeat elemental oscillator II. Exploring the parameter space
- 1 September 1995
- journal article
- research article
- Published by Springer Nature in Journal of Computational Neuroscience
- Vol. 2 (3) , 237-257
- https://doi.org/10.1007/bf00961436
Abstract
In the previous paper, we described a model of the elemental heartbeat oscillator in the leech. Here, the parameters of our model are explored around the baseline canonical model. The maximal conductances of the currents and the reversal potential of the leak current are varied to reveal the effects of individual currents and the interaction between synaptic and intrinsic currents in the model. The model produces two distinct modes of oscillation as the parameters are varied, S-mode and G-mode. These two modes are defined, their origin is identified, and the parameter space is mapped into S-mode and G-mode oscillation and no oscillation. Finally, we will make predictions for how the period can be modulated in heart interneurons.Keywords
This publication has 21 references indexed in Scilit:
- A persistent sodium current contributes to oscillatory activity in heart interneurons of the medicinal leechJournal of Comparative Physiology A, 1994
- Mechanisms for oscillation and frequency control in reciprocally inhibitory model neural networksJournal of Computational Neuroscience, 1994
- Motor-pattern-generating networks in invertebrates: modeling our way toward understandingTrends in Neurosciences, 1992
- Alternating and Synchronous Rhythms in Reciprocally Inhibitory Model NeuronsNeural Computation, 1992
- Plateaus in timeCurrent Biology, 1991
- Identification of RFamide neuropeptides in the medicinal leechPeptides, 1991
- Modulation of Neural Networks for BehaviorAnnual Review of Neuroscience, 1991
- Leydig neuron activity modulates heartbeat in the medicinal leechJournal of Comparative Physiology A, 1990
- Rate modification in the heartbeat central pattern generator of the medicinal leechJournal of Comparative Physiology A, 1984