A COMPARATIVE TRIAL OF CEFAZOLIN AND MOXALACTAM AS PROPHYLAXIS FOR PREVENTING INFECTION AFTER ABDOMINAL HYSTERECTOMY

  • 1 January 1985
    • journal article
    • research article
    • Vol. 66  (3) , 372-376
Abstract
In a randomized, double-blind clinical trial, 208 women who underwent abdominal hysterectomy received either cefazolin (N = 108) or moxalactam (N = 100) as perioperative antimicrobial prophylaxis. There were no differences between the 2 groups in rates of serious infection, minor wound infection, standard febrile morbidity, duration of hospitalization, proportion receiving other postoperative antibiotics or rates of rehospitalization. Women who received moxalactam had significantly more urinary tract infections, 87% of which were caused by the enterococcus. Apparently, perioperative prophylaxis with 3rd-generation cephalosporins is not justified at this time.

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