RELATION OF THE SUPRARENALS TO THE SYMPATHETIC NERVOUS SYSTEM

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Abstract
The existence of some sort of relationship between the suprarenals and the sympathetic nervous system was foreshadowed by Addison's and Brown-Séquard's observations seventy-five years ago that disease or destruction of these glands results in a train of symptoms in which circulatory weakness is a prominent feature. This probability was rendered almost a certainty by the work of Oliver and Schäfer and of Cybuski and Szymonowicz some thirty years ago. These observers showed that suprarenal extracts powerfully stimulate the arterioles to contract and the heart to beat more forcefully, results that are likewise brought about by sympathetic stimulation. These observers determined that the potent principle was obtainable from the medulla but not from the cortex of the gland. Elliot, in 1905, rounding out the investigations of Langley and Brodie and Dixon, determined that injections of suprarenal extracts and stimulation of sympathetic nerves give similar results throughout the body. This first half-century's

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