Kinetic resolution of amines by acylation using 3-diacylaminoquinazolin-4(3H)-ones
- 24 December 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 1,p. 43-44
- https://doi.org/10.1039/a907970j
Abstract
Four diastereoisomeric 3-diacylaminoquinazolinones 8a–d have been separated and identified by X-ray structure determinations on three of them: their stoichiometric reactions with α-phenylethylamine and with 2-methylpiperidine (2 equiv. of amine) gave the corresponding N-(2-acetoxypropanoyl)amine and unreacted amine in high diastereomeric/enantiomeric excess.Keywords
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