CHROMOSOMAL-ABERRATIONS AND SISTER-CHROMATID EXCHANGES INDUCED BY GASEOUS NITROGEN-DIOXIDE IN CULTURED CHINESE-HAMSTER CELLS
- 1 January 1981
- journal article
- research article
- Vol. 89 (4) , 303-309
Abstract
Effects of gaseous NO2 [one of the principal oxidants in urban photochemical smog] on chromosomal morphology of cultured Chinese hamster lung V79-H3 cells were investigated. Chinese hamster cells were exposed to NO2 gas in N2 gas at NO2 concentrations of 0, 5, 10, 20, 50 and 100 ppm vol/vol for 10 min at a gas flow rate of 1000 ml/min. Both chromosomal aberrations and sister chromatid exchanges were increased depending on the NO2 concentration. The effects of NaNO2 were also examined in comparison with those of gaseous NO2, and the effects of gaseous NO2 could not be ascribed to those of nitrous acid. The gas-exposure apparatus used in this experiment seems to be useful for quantitative investigation of the effects of various gaseous materials on cultured mammalian cells or bacterial cells.This publication has 4 references indexed in Scilit:
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