Electrographic Changes Associated with Cyclical Reduction of Coronary Blood Flow

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Abstract
Electrographic changes associated with cyclical reduction of blood flow in partially constricted 1 or 2 coronary arteries of anesthetized dogs were examined. In single vessel constriction preparations, cyclical ST elevation occurred along with cyclical reduction of coronary blood flow below 25% of the control value. The ST elevation occurred with reciprocal ST depression in the contralateral ventricular surface. In double vessel constriction preparations, cyclical reduction of flow frequently occurred in both vessels. The reduction of flow in 1 vessel occurred asynchronously with that in another vessel in the majority of preparations. The reduction of flow in both vessels was associated with ST elevation in the corresponding areas of the left ventricle. Premature ventricular contractions frequently occurred at the beginning of or immediately after disappearance of ST elevation, or when ST elevation persisted for > 10 min. Ventricular fibrillation frequently occurred in the double vessel constriction preparations.