The Requirement for the Fc Portion of Antibody in Antigen-Antibody Complex-Mediated Suppression
Open Access
- 1 May 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 120 (5) , 1669-1671
- https://doi.org/10.4049/jimmunol.120.5.1669
Abstract
The role of the Fc portion of antibody in immune complex-induced suppression was studied in vivo and in vitro. BSA pheasant anti-BSA complexes, formed in antigen excess (Ag1Ab1), were found to suppress both responses to BSA and SRBC. When complexes were formed with F(ab′)2 fragments of pheasant anti-BSA, no suppression was observed, indicating that the Fc piece was indeed essential for the induction of Ag-Ab complexmediated suppression.This publication has 2 references indexed in Scilit: