Highly Enantioselective Friedel−Crafts Alkylations of Pyrroles and Indoles with α‘-Hydroxy Enones under Cu(II)-Simple Bis(oxazoline) Catalysis
- 1 March 2005
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (12) , 4154-4155
- https://doi.org/10.1021/ja0423217
Abstract
Remarkably high and regular enantioselectivities are obtained in Friedel-Crafts alkylation reactions involving alpha'-hydroxy enone templates and Cu(II)-bis(oxazoline) complexes as catalysts. The simple elaboration of adducts provides a route to enantioenriched aldehydes, carboxylic acids, and ketones containing the pyrrole and indole frameworks.Keywords
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