HLA class II glycoprotein expression by monocytes from HIV-infected individuals: differences in response to interferon-gamma
- 28 June 2008
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 82 (3) , 553-558
- https://doi.org/10.1111/j.1365-2249.1990.tb05489.x
Abstract
The expression of HLA class II glycoproteins by monocytes from HIV-infected individuals was evaluated. We found no differences in HLA-DR, HLA-DQ, or HLA-DP expression by freshly isolated monocytes from patients with clinical AIDS, HIV-infected patients without AIDS or from uninfected individuals. However, monocytes from HIV-infected individuals without AIDS responded better to stimulation with recombinant human inteferon-gamma (IFN-.gamma.) than did monocytes from patients with clinical AIDS or from uninfected individuals. The response to IFN-.gamma. stimulation by monocytes from patients with clinical AIDS was different. Thus, the largest increases in the percentage of cells expressing HLA-DR was associated with the smallest changes in the fluorescence intensity of the population that is observed following stimulation of monocytes from other patient populations.Keywords
This publication has 14 references indexed in Scilit:
- The Human Immunodeficiency Virus: Infectivity and Mechanisms of PathogenesisScience, 1988
- Monocyte Phenotype and Function in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS‐Related DisordersScandinavian Journal of Immunology, 1987
- Human immunodeficiency virus infection down-regulates HLA class II expression and induces differentiation in promonocytic U937 cells.Journal of Clinical Investigation, 1987
- All human monocytes have the capability of expressing HLA-DQ and HLA-DP molecules upon stimulation with interferon-gamma.The Journal of Immunology, 1986
- Decreased expression of human class II antigens on monocytes from patients with acquired immune deficiency syndrome. Increased expression with interferon-gamma.Journal of Clinical Investigation, 1984
- Differential expression of Ia molecules by human monocytes.Journal of Clinical Investigation, 1984
- Antigen-Presenting Function of the MacrophageAnnual Review of Immunology, 1984
- Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules.Proceedings of the National Academy of Sciences, 1983
- The Use of the Avidin‐Biotin Complex as a Tool in Molecular BiologyPublished by Wiley ,1980
- Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.1968