THE NEED FOR THE PRESENCE OF CALCIUM FOR THE STIMULATIONIN VITROOF RAT ADRENAL GLANDS BY ADRENOCORTICOTROPHIC HORMONE

1 December 1953

journal article
research article
Published by The Endocrine Society in Endocrinology

Vol. 53 (6) , 687-689
https://doi.org/10.1210/endo-53-6-687

Abstract

Results of these expts. indicate that the presence of Ca in the medium is essential for the response of the adrenal of ACTH added in vitro, but that it has no effect on the steroid output in the absence of added ACTH. The mechanism of the Ca effect remains to be explained. It may be that Ca in the medium permits freer access of ACTH to the cellular mechanisms involved in steroid production, or that Ca is a cofactor in one of the reactions required for steroid forma-tion.

Keywords

ACTH/EFFECTS
ADRENAL GLANDS/PHYSIOLOGY
CALCIUM
TIME

This publication has 1 reference indexed in Scilit:

IN VITRO BIOASSAY OF CORTICOTROPHIN
Endocrinology, 1953