1-Amino-2-oxo-3-oxabicyclo[3.1.0]hexane (2,3-methanohomoserine lactone), a conformationally constrained amino acid
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 19,p. 1373-1374
- https://doi.org/10.1039/c39900001373
Abstract
A rapid high yielding synthesis of N-t-butoxycarbonyl-1-amino-2-oxo-3-oxabicyclo[3.1.0]hexane is described; the synthesis relies on an intramolecular carbenoid reaction of an appropriate malonate derivative followed by Curtius degradation to give the unprotected amino group.Keywords
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