Role of α-Adrenergic Mechanism in Regulating Tonic Luteinizing Hormone Release in Conscious Ovariectomized Rats*
- 1 April 1981
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 108 (4) , 1272-1275
- https://doi.org/10.1210/endo-108-4-1272
Abstract
The role of brain catecholamines in controlling tonic LH secretion was studied in unanesthesized, freely moving, ovariectomized rats. Pretreatment with reserpine (10 mg/kg), given 24 h before the experiment, significantly suppressed pulsatile LH secretion in these rats. Intraperitoneal administration of clonidine (1 mg/kg), an α-adrenergic stimulating agent, significantly raised plasma LH levels in reserpine-treated rats. On the other hand, the administration of apomorphine (1.5 mg/kg), a dopamine receptor-stimulating agent, had no effect on the plasma LH levels. These findings suggest an excitatory role of noradrenaline, operating through α-adrenergic receptors, in pulsatile LH secretion in ovariectomized rats.Keywords
This publication has 7 references indexed in Scilit:
- Monoaminergic Control of Episodic Growth Hormone Secretion in the Rat: Effects of Reserpine, a-Methyl-p-Tyrosine, p-Chlorophenylalanine, and Haloperidol*Endocrinology, 1979
- Effect of Intraventricular Infusion of Catecholamines on Luteinizing Hormone Release in Ovariectomized and Ovariectomized, Steroid-Primed RatsNeuroendocrinology, 1979
- Acute Effects of Adrenergic Receptor Blocking Drugs and Neuroleptic Agents on Pulsatile Discharges of Luteinizing Hormone in the Ovariectomized RatNeuroendocrinology, 1978
- Serotonin Mediated Inhibition of Episodic Luteinizing Hormone Release During Electrical Stimulation of the Arcuate Nucleus in Ovariectomized Rats12Endocrinology, 1977
- Further Evidence for Inhibition of Episodic Luteinizing Hormone Release in Ovariectomized Rats by Stimulation of Dopamine Receptors1Endocrinology, 1977
- Catecholamine Involvement in Episodic Luteinizing Hormone Release in Adult Ovariectomized Rats12Endocrinology, 1976
- Involvement of Catecholaminergic and Cholinergic Mechanisms in the Pulsatile Release of LH in the Long-Term Ovariectomized RatNeuroendocrinology, 1976