Soft-Tissue Damage Associated with Intravenous Phenytoin

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Abstract
To the Editor: Phenytoin (Dilantin, Parke–Davis) has been widely administered as an anticonvulsant by direct intravenous injection. Within a 25-month period, we have observed serious local reactions in nine patients receiving intravenous phenytoin. In only one instance was there documentable evidence of infiltration of the drug. The age of the patients ranged from 18 to 82 years, with a mean of 64.8; eight were female. In three patients, phenytoin was the only drug administered intravenously. Intravenous drugs administered in the other six patients consisted of cefazolin, cefoxitin, cimetidine, dexamethasone, diazepam, and phenobarbital.The reactions have generally consisted of a delayed . . .

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