Serum granulocyte colony-stimulating factor in patients with repeated infections

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Abstract
We have already reported significant elevation of serum granulocyte colony-stimulating factor (G-CSF) in the acute phase of infection. In this study, we compared the responses to infection between patients with frequently repeated infection (repeaters) and others (non-repeaters). We examined the clinical data and serum G-CSF levels in 48 patients with acute infections. Serum G-CSF levels were significantly lower in repeaters than in non-repeaters (197.7 ± 370.0 vs. 1014.1 ± 924.4 pg/ml. P < 0.001). There were no significant differences in age, serum total protein, or cholinesterase between the groups, but serum albumin was significantly lower in repeaters than in non-repeaters (2.87 ± 0.5 vs. 3.31 ± 0.4 g/dl. P < 0.005). It is suggested that administration of recombinant G-CSF may be useful for patients with repeated infections.