1H NMR study on the conformation of bacitracin A in aqueous solution
- 29 June 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 305 (2) , 105-109
- https://doi.org/10.1016/0014-5793(92)80874-g
Abstract
The conformation of bacitracin A, a widely used cyclic dodecapeptide antibiotic in aqueous solution, has been investigated using 500 MHz 1H NMR and molecular modeling. Findings revealed that a region (residues 1–6) is folded over the cyclic ring, resulting in metal coordination sites, a thiazoline ring, and Glu4 and His10 being proximate to each otherKeywords
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