An In Vivo and In Vitro Study of an Aging-related Neuron Cytoplasmic-binding Antibody in Male Fischer Rats

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Abstract
Fischer 344 male rats showed a low average level (less than + +) of in vivo as well as in vitro neuron binding antibody at 3,15, and 26 months. However, a significant increase with age in average intensity of binding was observed with both the in vivo and the in vitro conditions. If a criterion of + + is used as an antibody binding level likely to have biological consequences, the percent of in vivo cases showing foci of + + or greater intensity also rises with age from 20 to 80%; a criterion of + + + gives an in vivo rise with age of only from 10 to 20%. The in vitro incidence with the + + criterion is already 80% at three months and rises to 90%; with the + ++ criterion the incidence with age rises from 20 to 80%. No evidence was obtained to support the concept that there is a weakening of the blood-brain-barrier in 26 month rats either by the systemic injection of trypan blue or by a comparison of intensity of antibody binding between extraand intra-barrier neurones.

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