In VitroandIn VivoAntitumoral Phenanthrenes from the Aerial Parts ofDendrobium nobile
- 1 April 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 61 (02) , 178-180
- https://doi.org/10.1055/s-2006-958043
Abstract
Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl. and their structures were identified to be 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which the former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV-3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukemia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 × 106 cells of sarcoma 180.Keywords
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