Identification of a 2-D geometric descriptor associated with nongenotoxic carcinogens and some estrogens and antiestrogens
Open Access
- 1 January 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 11 (1) , 95-100
- https://doi.org/10.1093/mutage/11.1.95
Abstract
A distance descriptor (6Â) originally associated with nongenotoxic mouse carcinogens has been found to be present in some, but not all, estrogens and antiestrogens. It is hypothesized that this descriptor describes a ligand binding site on an estrogen receptor. Evidence is presented that those estrogens and antiestrogens not containing the 6Â distance bind to a different receptor. It is conceivable that binding to the receptor that recognizes the 6Â distance is associated with carcinogenicity.Keywords
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