Cryopreservation of insulin‐producing tissue in rats and dogs
- 1 April 1984
- journal article
- research article
- Published by Wiley in World Journal of Surgery
- Vol. 8 (2) , 179-186
- https://doi.org/10.1007/bf01655133
Abstract
Transplantation of frozen‐thawed islets of Langerhans normalized urine volume, urine glucose, plasma glucose, and weight gain in diabetic rats. However, these animals had abnormal intravenous glucose tolerance tests (ivGTT) at 3 mo post‐transplant. Modified cryopreservation protocols were extended to canine islet‐containing tissue: a higher temperature was used during equilibration in the 2 M dimethyl sulfoxide. Recipients of frozen‐thawed isografts had prolonged normoglycemia with plasma glucose .Keywords
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