No Antioxidant Effect of Combined HRT on LDL Oxidizability and Oxidative Stress Biomarkers in Treated Post-Menopausal Women

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Abstract
Objective: To compare oxidative stress and LDL oxidizability in postmenopausal women with and without HRT. Methods: In a cross sectional study, two groups of women, with or without combined per os HRT (1.5–2 mg estrogen associated with 10 mg dydrogesteron), were age and duration of menopause matched. Women were recruited after medical examination at LBSO (Oxidative Stress Laboratory), Joseph Fourier University, Grenoble, and Department of Gynecology, Grenoble University Hospital, France. Main outcome measures included determination of lipid profile and oxidative stress biomarkers (TBARS, LDL oxidizability, auto-antibodies against oxidized-LDL). Measurement of circulating levels of vitamin C, E, β-carotene, lycopene and total antioxidant plasma capacity. Results: HRT led to decreased plasma total and LDL cholesterol (p < 0.05), but did not affect oxidizability and oxidation of LDL. Circulating levels of antioxidant vitamins (β-carotene, vitamin C, vitamin E/triglycerides) and total antioxidant capacity of plasma and lipid peroxidation, assessed by plasma TBARs, were not different from controls in postmenopausal women receiving HRT. Conclusion: This study suggests that even if combined HRT modifies the blood lipid profile, it does not appear to influence oxidative status.