ANTIBODY-DEPENDENT LYMPHOCYTE-MEDIATED CYTOTOXICITY (Ab-LMC), DEFINITION OF THE “K CELL” IN THE RAT

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Abstract
The nature and membrane characteristics of the K cell of antibody-dependent lymphocyte-mediated cytotoxicity (Ab-LMC) were investigated in a widely used rat model of transplantation. Treatment of sensitized effector cell populations with anti-immunoglobulin [Ig] and complement eliminated K cell cytotoxicity without diminishing the component of T [thymus-dependent] cell-mediated injury. EA [erythrocyte-antibody] and EAC [erythrocyte-antibody-complement] depletion experiments, although demonstrating no loss of K cell cytotoxicity after removal of complement receptor-bearing lymphocytes, produced a marked abrogation of cytotoxicity following the removal of the Fc [Ig fragment] receptor-bearing lymphocyte pool. Studies on phagocytic properties showed K cell activity to be shared by an adherent and a nonadherent cell population. The Fc receptor emerged as the only constant surface marker of the rat K cell in Ab-LMC.

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