Platelet surface antigens: Analysis by monoclonal antibodies
- 1 March 1984
- journal article
- research article
- Published by Springer Nature in Annals of Hematology
- Vol. 48 (3) , 161-170
- https://doi.org/10.1007/bf00320339
Abstract
Monoclonal antibodies were produced against human platelets. Four antibodies (PA1, PA2, PA3 and PA4) reacted specifically with platelets and megakaryocytes, but not with peripheral blood lymphocytes, granulocytes, erythrocytes or monocytes. The antibodies belonged to the mouse IgG subclass 2a (PA1, PA2, PA3), or 1 (PA4) respectively. PA1 and PA4 did not precipitate, their antigens have not yet fully been characterized. PA3 was directed against the glycoprotein (Gp) complex IIb/IIIa; PA2 precipitated Gp IIb/IIIa, and, in addition, Gp Ia. PA4 revealed specificity against the human platelet alloantigen Zw(a).Keywords
This publication has 34 references indexed in Scilit:
- Monoclonal Antibodies against Platelet Membrane Glycoproteins. Characterization and Effect on Platelet FunctionEuropean Journal of Biochemistry, 1983
- HLA‐B7 on human red blood cells. Improved detection by a radioactive anti‐IgG test*Tissue Antigens, 1982
- Monoclonal Antibody to Human Platelet Glycoprotein I II. EFFECTS ON HUMAN PLATELET FUNCTIONBritish Journal of Haematology, 1981
- Glycoproteins of Platelet Membranes from Glanzmann's Thrombasthenia. A Comparison with Normal Using Carbohydrate-Specific or Protein-Specific Labelling Techniques and High-Resolution Two-Dimensional Gel ElectrophoresisEuropean Journal of Biochemistry, 1981
- Hairy Cell Leukaemia: Surface Markers and Functional Capacities of the Leukaemic Cells Analysed in Eight PatientsBritish Journal of Haematology, 1979
- Absence of the platelet receptor for drug-dependent antibodies in the Bernard-Soulier syndrome.Journal of Clinical Investigation, 1978
- A plaque assay for all cells secreting Ig of a given type or classEuropean Journal of Immunology, 1976
- Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by FluorographyEuropean Journal of Biochemistry, 1975
- Continuous cultures of fused cells secreting antibody of predefined specificityNature, 1975
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970