Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments
- 1 February 1979
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 277 (5698) , 627-633
- https://doi.org/10.1038/277627a0
Abstract
A 6.8-kilobase DNA fragment containing the sequence coding for the constant region of the mouse immunoglobulin .gamma.1 H chain was cloned from total cellular DNA. EM and nucleotide sequencing studies showed that the 3 protein domains and the hinge region are encoded in separate DNA segments.Keywords
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