Linkage of plasma α‐L‐fucosidase (FUCA2) and the plasminogen (PLG) system

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Abstract
Plasma fucosidase (FUCA2) was examined by means of a technique using p-nitrophenyl-.alpha.-L-fucopyranoside as substrate. The material consisted of normal Danish families, including 1672 unrelated persons (parents). In this material the low activity allele frequency was found to be plow = 0.286 which agrees with earlier studies in European populations. The allele frequencies did not differ significantly between the sexes. Segregation ratios agreed with the hypothesis that low is due to an autosomal recessive allele. The results give a strong indication of linkage for FUCA2-PLG [plasminogen] (.cxa.z = 7.37 .theta. = 0.12) in males, and the linkage may be considered as formally demonstrated. The PLG-system as judged from the indication of linkage of GC [group-specific component] (.cxa.z = 2.35, .theta. = 0.30 in males) is then possibly located on chromosome 4p.