Antimicrobial properties of porphyrins
- 24 February 2001
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Investigational Drugs
- Vol. 10 (2) , 309-320
- https://doi.org/10.1517/13543784.10.2.309
Abstract
A large number of natural and synthetic porphyrins of diverse chemical compositions and characteristics can be isolated from nature or synthesised in the laboratory. Antimicrobial and antiviral activities of porphyrins are based on their ability to catalyse peroxidase and oxidase reactions, absorb photons and generate reactive oxygen species (ROS) and partition into lipids of bacterial membranes. Light-dependent, photodynamic activity of natural and synthetic porphyrins and pthalocyanines against Gram-positive and Gram-negative bacteria has been well demonstrated. Some non-iron metalloporphyrins (MPs) possess a powerful light-independent antimicrobial activity that is based on the ability of these compounds to increase the sensitivity of bacteria to ROS or directly produce ROS. MPs mimic haem in their molecular structure and are actively accumulated by bacteria via high affinity haem-uptake systems. The same uptake systems can be used to deliver antibiotic-porphyrin and antibacterial peptide-porphyrin con...Keywords
This publication has 73 references indexed in Scilit:
- δ-Aminolaevulinic acid-induced porphyrin synthesis and photodynamic inactivation of Escherichia coli B.Journal of Photochemistry and Photobiology B: Biology, 1999
- STRUCTURE‐ACTIVITY RELATIONSHIP OF PORPHINES FOR PHOTOINACTIVATION OF BACTERIAPhotochemistry and Photobiology, 1995
- Transport of haemin across the cytoplasmic membrane through a haemin‐specific periplasmic binding‐protein‐dependent transport system in Yersinia enterocoliticaMolecular Microbiology, 1994
- Three-Dimensional Structure-Activity Analysis of a Series of Porphyrin Derivatives with Anti-HIV-1 Activity Targeted to the V3 Loop of the gp120 Envelope Glycoprotein of the Human Immunodeficiency Virus Type 1Journal of Medicinal Chemistry, 1994
- The antibacterial activity of haemin compared with cobalt, zinc and magnesium protoporphyrin and its effect on pottassium loss and ultrastructure ofStaphylococcus aureusFEMS Microbiology Letters, 1993
- Chemistry and Biology of Heme Effect of Metal Salts, Organometals, and Metalloporphyrins on Heme Synthesis and Catabolism, with Special Reference to Clinical Implications and Interactions with Cytochrome P-450Drug Metabolism Reviews, 1993
- Specific inhibition of HIV-1 protease by boronated porphyrinsJournal of Medicinal Chemistry, 1992
- Porphyrin‐linked oligonucleotidesFEBS Letters, 1990
- Sir, Anti-HIV activity of protoporphyrinAIDS, 1989
- Hemin inhibits virion-associated reverse transcriptase of murine leukemia virusBiochemical and Biophysical Research Communications, 1987