ACID AND ALKALINE PHOSPHATASES IN OVARIAN TISSUES OF THE RAT DURING PREGNANCY AND LACTATION1,2

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Abstract
The Huggins-Talalay method for phosphatase detn. was adapted to the detn. of acid and alkaline phosphatases in the corpus luteum and corpus luteum free ovarian residue of the rat in diestrus, pregnancy, and lactation. Acid phosphatase was present in lesser quantity than alkaline phosphatase at all times in all tissues studied. The acid phosphatase activity/ unit wt. of the corpora of pregnancy rises slightly in mid-pregnancy, remaining at this level until after parturition. In the corpora of lactation, it rises slowly throughout the life of the corpora. The alkaline phosphatase/unit wt. of the corpora of pregnancy rises from its initial low level early in pregnancy and again between days 10 and 14, continuing to rise after parturition. The alkaline phosphatase rises in the corpora of lactation through the 15th day of lactation, falling between days 15 and 20. The rion-lutein ovarian tissue presents unchanging acid phosphatase activity throughout the periods studied. The alkaline phosphatase activity of the ovarian residue is somewhat higher in lactation than in pregnancy, and drops markedly in the first half of pregnancy and toward the end of lactation. Significance .of the results is discussed.

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