OPIATE RECEPTOR-BINDING AND ANALGESIC EFFECTS OF THE TETRAHYDROISOQUINOLINES SALOLINOL AND TETRAHYDROPAPAVEROLINE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 27  (1) , 3-16
Abstract
Salsolinol and tetrahydropapaveroline bind to opiate receptors in rat brain with affinities of 6.2 and 1.95 .times. 10-5 M, respectively. Their ability to displace 3H-naloxone is decreased about 4-fold by 100 mM Na ion. Both agents have antinociceptive effects when given to rats intraventricularly. Their potency is comparable to the enkephalins and their effect is blocked by naloxone.

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