Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates
Open Access
- 4 October 2007
- journal article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 7 (1) , 187
- https://doi.org/10.1186/1471-2148-7-187
Abstract
Progressive diversification of paralogs after gene expansion is essential to increase their functional specialization. However, mode and tempo of this divergence remain mostly unclear. Here we report the comparative analysis of PRDM genes, a family of putative transcriptional regulators involved in human tumorigenesis.Keywords
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