Trimethoprim-Sulfamethoxazole in Children: Pharmacokinetics and Clinical Studies

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Abstract
Trimethoprim-sulfamethoxazole (TMP-SMZ) was administered to five pediatric patients with defined infections. The pharmacokinetics were studied by measurement of levels of the drug in blood and urine during the first 96 hr of therapy. The five organisms tested were sensitive to the combination therapy. Therapeutically effective levels of TMP-SMZ were readily achieved in children with medication administered at 8-hr intervals. Serum ratios of SMZ to TMP approached 20:1 and were maintained after the first 24 hr of therapy.