Restless legs syndrome in uremic neuropathy

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Abstract
Five cases of uremia and the restless legs syndrome have been described. In all 5 cases some dysfunction of peripheral nerves was present. In 4, signs of peripheral neuropathy were only apparent by slow motor nerve conduction rates. This condition could result from defective peripheral nerve function or may originate in the nature of a specific toxin affecting peripheral nerves or as a result of the paresthesia and dysesthesia of damaged fibers in susceptible individuals.

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