To the Editor: It was interesting to read the letter of Dr. Donahoe and Dr. Powers in the Journal (282:690, 1970) describing their experience with intravenous administration of 5 per cent and 10 per cent solutions of xylitol in water to normal adult volunteers. They reported hyperuricemia with hyperuricosuria in two studies, with the occurrence of hyperbilirubinemia, mainly in the unconjugated form, in some subjects.Our experience with xylitol consists of intravenous administration of mainly 20 per cent solutions in water to hospital patients requiring additional calories parenterally. Smaller amounts of 10 per cent and 50 per cent solutions were . . .