Calcific Band Keratopathy Associated With the Use of Topical Steroid-Phosphate Preparations

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Abstract
Objective: To report a possible adverse effect of topical steroid-phosphate preparations and to identify factors that may contribute to the development of this effect. Design: The medical records of five patients who developed calcium deposition in the cornea were reviewed and analyzed for possible contributing factors. Patients: Five cases of calcium deposition in the cornea associated with the use of topical steroid-phosphate preparations are described. Scrapings from the cornea and/or specimens obtained at keratoplasty were available in all cases. These cases had the following characteristics in common: use of steroidphosphate preparations (n=5); multiple topical drops (n=5); penetrating keratoplasty (n=3); presence of epithelial defects (n=4); history of herpetic stromal keratitis (n=4); and history of iritis (n=3). A hypothesis explaining calcium deposition in association with steroid-phosphate preparations is presented. Conclusions: We recommend withdrawal of steroidphosphate preparations in patients who develop band keratopathy.

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