Procollagen III peptide (PIIIP): Can it reflect hepatic fibrosis?
Open Access
- 1 September 1987
- journal article
- editorial
- Published by Wolters Kluwer Health in Hepatology
- Vol. 7 (5) , 981-983
- https://doi.org/10.1002/hep.1840070538
Abstract
Immunolocalization of type III collagen and procollagen in cirrhotic human liver was studied using monoclonal antibody specific for the helical determinant of type III collagen extracted from human placenta. Deparaffinized, trypsin-treated cirrhotic liver sections from 8 autopsy cases were examined by the unlabeled peroxidase-antiperoxidase and immunofluorescence techniques. These techniques revealed the localization of this epitope shared by type III collagen and procollagen not only in the extracellular matrix of hepatocytes and sinusoidal cells but also in the cytoplasm. In hepatocellular carcinoma concurrent with cirrhosis, neoplastic cells were shown to react with this antibody as well. These results are consistent with data obtained using antiserum specific for bovine type III procollagen aminopeptide which appeared in our previous report.Keywords
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