L-Asparaginase: Toxicity to Normal and Leukemic Human Lymphocytes
- 20 January 1967
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 155 (3760) , 329-330
- https://doi.org/10.1126/science.155.3760.329
Abstract
Quantitative in vitro tests showed that purified preparations of L-asparaginase from Escherichia coli were more toxic to blood lymphocytes from 12 of 15 patients with chronic lymphocytic leukemia than to lymphocytes from 25 persons with normal hemograms. Incubation for 7 days with 10 units per milliliter killed, on the average, 77 percent of leukemic and 34 percent of normal lymphocytes. The reagent produced appreciable toxicity to leukemic lymphocytes after 2 days of incubation.Keywords
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